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Prostate cancer

Commonly used medications cause clinically relevant decreases in serum PSA levels

Nature Reviews Urology volume 7, page 531 (2010)Cite this article

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The use of PSA measurement as a screening tool for prostate cancer is a widespread practice. However, many factors can influence PSA levels, including age, the presence of prostatitis, and prostate size. In addition, studies have suggested that several medications might affect PSA, such as NSAIDs and statins. Chang and colleagues at the Stanford University School of Medicine analyzed data from the National Health and Nutrition Examination Survey to study the effects of 10 classes of commonly used medications on PSA levels in 1,864 men aged ≥40 years.

...the underlying mechanisms driving these associations are unclear...

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ORIGINAL RESEARCH PAPER

  1. Chang, S. L. et al. Impact of common medications on serum total prostate-specific antigen levels: analysis of the National Health and Nutrition Examination Survey. J. Clin. Oncol. 28, 3951–3957 (2010)

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  1. Nick Warde
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Warde, N. Commonly used medications cause clinically relevant decreases in serum PSA levels. Nat Rev Urol 7, 531 (2010). https://doi.org/10.1038/nrurol.2010.149

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