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Penile cancer

New nomogram accurately predicts risk of metastasis in men with clinically negative lymph nodes

Nature Reviews Urology volume 7, page 596 (2010)Cite this article

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Researchers at the Fudan University Shanghai Cancer Center in China have designed and tested a nomogram that outperforms the European Association of Urology (EAU) risk classification in identifying patients with penile cancer at high risk of occult lymph node metastasis. “We wanted to provide a risk-based approach for better selection of treatment options,” says lead author Yao Zhu.

Zhu and colleagues gathered clinicopathological information from 110 men with penile squamous cell carcinoma and clinically negative inguinal lymph nodes (defined as either impalpable nodes or palpable nodes that were negative on fine needle aspiration biopsy). T stage, grade, lymphovascular invasion and p53 expression were found to be associated with positive lymph node status on pathology, and so these features were used to construct a nomogram.

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ORIGINAL RESEARCH PAPER

  1. Zhu, Y. et al. Development and evaluation of a nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes. J. Urol. 184, 539–545 (2010)

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  1. Sarah Payton
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Payton, S. New nomogram accurately predicts risk of metastasis in men with clinically negative lymph nodes. Nat Rev Urol 7, 596 (2010). https://doi.org/10.1038/nrurol.2010.177

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  • DOI: https://doi.org/10.1038/nrurol.2010.177

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