Trigonal injection of botulinum toxin-A improves outcome

Payton, Sarah

doi:10.1038/nrurol.2010.197

Research Highlight
Published: 08 December 2010

Incontinence

Trigonal injection of botulinum toxin-A improves outcome

Sarah Payton

Nature Reviews Urology volume 7, page 648 (2010)Cite this article

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Second-line treatment of neurogenic bladder typically consists of a botulinum toxin-A (BTX-A) injection directly into the detrusor. New data, however, from a study carried out by Taha Abdel-Meguid at Abdulaziz University Hospital in Jeddah, Saudi Arabia, suggest that including the trigone in the injection protocol can significantly improve short-term results.

“The trigone is known to be extensively innervated and its smooth muscles are very sensitive to small changes in pressure,” explains Abdel-Meguid. “In clinical practice, many of our patients with overactive bladder describe prompt urgency and/or urinary incontinence on rising from a sitting to standing position, further implicating involvement of the trigone in these symptoms.”

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ORIGINAL RESEARCH PAPER

Abdel-Meguid, T. A. Botulinum toxin-A injections into neurogenic overactive bladder—to include or exclude the trigone? A prospective, randomized, controlled trial. J. Urol. 184, 2423–2428 (2010)

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