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Prostate cancer

Colorectal cancer increased by ADT?

Nature Reviews Urology volume 8, page 2 (2011)Cite this article

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Androgen deprivation therapy (ADT), using orchidectomy or gonadotropin-releasing hormone (GnRH) agonists, is a first-line treatment for prostate cancer. A study published in the Journal of the National Cancer Institute has raised concerns regarding a putative link between ADT and the development of colorectal cancer.

The authors searched the Surveillance, Epidemiology, and End Results (SEER)–Medicare database and identified 107,859 men who had been diagnosed with prostate cancer between 1993 and 2002, over 55,000 of whom had received GnRH agonists or undergone orchidectomy. They then determined the proportion of these men who had been diagnosed with a secondary colorectal malignancy. The analysis showed that the incidence of colorectal cancer was highest in the orchidectomy group, intermediate in the GnRH agonist group, and lowest for those who had not received ADT.

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ORIGINAL RESEARCH PAPERS

  1. Gillessen, S. et al. Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer. J. Natl Cancer Inst. 1s02, 1760–1770 (2010)

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  1. Annette Fenner
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Fenner, A. Colorectal cancer increased by ADT?. Nat Rev Urol 8, 2 (2011). https://doi.org/10.1038/nrurol.2010.216

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