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Bladder cancer

Systematic support for photodynamic diagnosis

Nature Reviews Urology volume 7, page 175 (2010)Cite this article

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Two new systematic reviews draw the same encouraging conclusions regarding the utility of fluorescence cystoscopy for the detection of bladder malignancy.

The fluorochrome 5-aminolevulinic acid and its ester derivative hexaminolevulinate can be safely instilled in the bladder, where they preferentially accumulate in neoplastic tissue. Malignant areas appear red, and normal tissue blue, when the bladder surface is illuminated with blue–violet light via a rigid cystoscope.

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ORIGINAL RESEARCH PAPERS

  1. Mowatt, G. et al. Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer. Health Technol. Assess. 14, 1–331 (2010)

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  2. Kausch, I. et al. Photodynamic diagnosis in non-muscle-invasive bladder cancer: a systematic review and cumulative analysis of prospective studies. Eur. Urol. doi:10.1016/j.eururo.2009.11.041

  3. Witjes, J. A. et al. Hexaminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer: review of the evidence and recommendations. Eur. Urol. doi:10.1016/j.eururo.2010.01.025

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Authors
  1. Suzanne J. Farley
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Farley, S. Systematic support for photodynamic diagnosis. Nat Rev Urol 7, 175 (2010). https://doi.org/10.1038/nrurol.2010.28

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  • DOI: https://doi.org/10.1038/nrurol.2010.28

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