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Nature Reviews Urology volume 7, page 236 (2010)Cite this article

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Most patients with clear cell renal cell carcinoma (RCC) harbor inactivating mutations of the VHL gene. A UK Cancer Genome Project team has refined our understanding of the heterogeneous genetics of this malignancy by identifying inactivating mutations in genes that encode the histone-modification enzymes SETD2 and JARID1C (KDM5C). More than 3,500 protein-coding genes from 101 cases of clear cell RCC were sequenced. The findings indicate a key role for aberrant chromatin modification in human cancer.

The published evidence supporting laparoscopic surgery for localized renal cancer is of poor quality. This is the conclusion of a systematic review conducted by the Cochrane Collaboration. A comprehensive literature search failed to detect any randomized comparisons of open radical nephrectomy versus laparoscopic approaches, radiofrequency or cryoablation. Claims regarding advantages of laparoscopic surgery, such as hastened patient recovery and less blood loss, have been made on the basis of small, retrospective studies and case series.

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ORIGINAL RESEARCH PAPERS

  1. Dalgliesh, G. L. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360–363 (2010)

    Article  CAS  Google Scholar 

  2. Nabi, G., Cleves, A. & Shelley, M. Surgical management of localised renal cell carcinoma. Cochrane Database Syst. Rev. 3, CD006579 (2010)

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  3. Bernhard, J. C. et al. Predictive factors for ipsilateral recurrence after nephron-sparing surgery in renal cell carcinoma. Eur. Urol. doi: 10.1016/j.eururo.2010.02.019

  4. Bellmunt, J. et al. Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: a phase 2 study (SOGUG-02-06). Lancet Oncol. doi: 10.1016/S1470-2045(09)70383-3

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In brief. Nat Rev Urol 7, 236 (2010). https://doi.org/10.1038/nrurol.2010.55

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  • DOI: https://doi.org/10.1038/nrurol.2010.55

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