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Prostate cancer

PET–CT for pelvic node staging

Nature Reviews Urology volume 8, page 649 (2011)Cite this article

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[11C]choline PET–CT could be an effective and noninvasive method for identifying patients with high-risk prostate cancer who need pelvic radiotherapy. Following on from promising preliminary studies of [11C]choline PET, Contractor and colleagues have published data to show that a combined PET–CT multimodality imaging approach can further enhance the detection of pelvic lymph node metastases.

Node dissection is the current gold standard for pelvic lymph node detection, but it is invasive, lacks reliability, and has associated morbidity. Although MRI and CT offer alternatives, these investigations are less sensitive. However, PET can provide functional information relating to tissue activity, thus generating superior staging information.

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ORIGINAL RESEARCH PAPER

  1. Contractor, K. B. et al. Use of [11C]choline PET-CT as a non-invasive method for detecting pelvic lymph node status from prostate cancer and relationship with choline kinase expression. Clin. Cancer Res. doi:10.1158/1078-0432.CCR-11-2048

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  1. Melanie Clyne
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Clyne, M. PET–CT for pelvic node staging. Nat Rev Urol 8, 649 (2011). https://doi.org/10.1038/nrurol.2011.184

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