POP goes the smooth muscle contractile protein

Warde, Nick

doi:10.1038/nrurol.2011.185

Research Highlight
Published: 22 November 2011

Genetics

POP goes the smooth muscle contractile protein

Nick Warde

Nature Reviews Urology volume 8, page 650 (2011)Cite this article

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Biopsy samples of the anterior vaginal wall were taken from 55 women during total hysterectomy for stage ≥3 POP (cases) or benign conditions (controls). Of these women, 37 were premenopausal (23 cases and 14 controls) and 18 were postmenopausal (13 cases and 5 controls). Gene expression was assessed using real-time PCR.

In the premenopausal women, only MHY11 expression was significantly downregulated in patients with POP compared to controls (fivefold decrease, P = 0.0002). In the analysis of postmenopausal women, CALD1 expression was sixfold higher in cases compared to controls (P = 0.03), and ACTG2 expression was increased sixfold (although this difference was not quite statistically significant). When the expression profiles of the premenopausal and postmenopausal controls were compared, all four of the study genes were found to be decreased after the menopause, significantly so in the cases of CALD1, ACTG2 and TPM1.

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ORIGINAL RESEARCH PAPER

Bortolini, A. T. et al. Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse. Neurourol. Urodynam. doi:10.1002/nau.21175
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