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Prostate cancer

Does denosumab have a role in metastasis prevention?

Nature Reviews Urology volume 9, page 1 (2012)Cite this article

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Results of a large phase III randomized controlled trial—recently published online in the Lancet—have shown that denosumab can delay the onset of bone metastasis in patients with castration-resistant prostate cancer (CRPC). The question now is how this finding should be translated into clinical practice—could denosumab be administered as a preventative agent in patients who have CRPC that has not yet spread to bone?

Denosumab is a human monoclonal antibody raised against the receptor activator of nuclear factor κB ligand (RANKL). It was approved by the FDA for the prevention of bone-related events in patients with metastatic prostate cancer based on phase III trial data published earlier this year, which demonstrated that denosumab could delay such events for longer than zoledronic acid in men with confirmed bone metastasis.

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ORIGINAL RESEARCH PAPER

  1. Smith, M. R. et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet doi:10.1016/S0140-6736(11)61226-9

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  1. Sarah Payton
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Payton, S. Does denosumab have a role in metastasis prevention?. Nat Rev Urol 9, 1 (2012). https://doi.org/10.1038/nrurol.2011.196

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  • DOI: https://doi.org/10.1038/nrurol.2011.196

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