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Prostate cancer

Androgen deprivation causes EMT in the prostate

Nature Reviews Urology volume 9, page 4 (2012)Cite this article

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Androgen deprivation causes epithelial–mesenchymal transition (EMT) in both healthy and cancerous prostate tissue, according to a team of researchers from San Francisco, USA. This process is thought to be mediated by a negative feedback loop between the androgen receptor and Zeb1.

In the first set of experiments, Sun et al. evaluated the gene expression profiles of intact and castrated mouse prostates. 3 days postcastration, N-cadherin, Twist1 and Slug expression levels were upregulated. These increases were reversed upon testosterone replenishment. Similar changes were observed in tumor biopsies from patients and SLUG was one of the top-ranking genes for expression status 14 days after chemical castration.

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ORIGINAL RESEARCH PAPER

  1. Sun, Y. et al. Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res. doi:10.1158/0008-5472.CAN-11-3004

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  1. Melanie Clyne
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Clyne, M. Androgen deprivation causes EMT in the prostate. Nat Rev Urol 9, 4 (2012). https://doi.org/10.1038/nrurol.2011.208

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