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Prostate cancer

Genetic risk analysis goes global

Nature Reviews Urology volume 11, page 661 (2014)Cite this article

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A meta-analysis of nine genome-wide association studies (GWAS) involving men of diverse ancestries has identified 23 new prostate cancer susceptibility loci, taking the current total of known loci to 100, that between them explain 33% of familial risk in European-ancestry populations.

Genetic predisposition to prostate cancer can be determined by GWAS of single-nucleotide polymorphisms (SNPs). Loci that are identified by GWAS can be used to calculate the risk of disease in individuals, and to highlight genomic regions for further investigation in mechanistic and therapeutic studies.

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References

  1. Al Olama, A. A. et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat. Genet. 10.1038/ng.3094

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Authors
  1. Robert Phillips
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Phillips, R. Genetic risk analysis goes global. Nat Rev Urol 11, 661 (2014). https://doi.org/10.1038/nrurol.2014.277

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  • DOI: https://doi.org/10.1038/nrurol.2014.277

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