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Infection

Blocking bacterial biofilms on urinary bladder catheters

Nature Reviews Urology volume 11, page 660 (2014)Cite this article

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New research has identified an interaction between a bacterial protein and fibrinogen that is found in the murine bladder following catheterization, enabling formation of a bacterial biofilm on the catheter, which is prevented by vaccination of mice with the bacterial protein.

Catheter-associated urinary tract infections (CAUTIs) are the most common cause of hospital-acquired infections. The emergence of drug-resistant bacteria has reduced available treatment options for CAUTIs, and new therapeutic strategies are urgently required.

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References

  1. Flores-Mireles, A. L. et al. EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice. Sci. Transl. Med. 6, 254ra127 (2014)

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  1. Robert Phillips
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Phillips, R. Blocking bacterial biofilms on urinary bladder catheters. Nat Rev Urol 11, 660 (2014). https://doi.org/10.1038/nrurol.2014.281

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  • DOI: https://doi.org/10.1038/nrurol.2014.281

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