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Prostate cancer

Copper unlocks therapeutic potential of disulfiram

Nature Reviews Urology volume 11, page 664 (2014)Cite this article

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Copper supplementation is required for cytotoxicity of disulfiram in prostate cancer cells and could be essential for therapeutic efficacy of this agent in men with prostate cancer, according to a study published in Cancer Research.

Elevated circulating and intracellular copper levels have previously been found in men with prostate cancer, but the potential of this attribute as a therapeutic target was unclear. Now, Rachid Safi and colleagues from Duke University, NC, USA, investigated whether the copper signalling axis could be exploited as a therapeutic modality.

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References

  1. Safi, R. et al. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 74, 5819–5831 (2014)

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  1. Clemens Thoma
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Thoma, C. Copper unlocks therapeutic potential of disulfiram. Nat Rev Urol 11, 664 (2014). https://doi.org/10.1038/nrurol.2014.303

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