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Kidney cancer

New genomic variation found

Nature Reviews Urology volume 12, page 67 (2015)Cite this article

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The first comprehensive genomic analysis comparing subtypes of nonclear cell renal carcinoma (nccRCC) has been published in Nature Genetics. The findings of this investigation have implications for the accurate presurgical diagnosis of distinct nccRCC tumour types and also provide new therapeutic targets for this disease.

nccRCC accounts for approximately 25% of renal cell carcinoma (RCC) diagnoses and is comprised of distinct tumour subtypes including papillary RCC (pRCC), chromophobe RCC (chRCC) and translocation RCC (tRCC). Identification of chRCC, in particular, is difficult as tumour features often overlap with those of benign renal oncocytoma.

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References

  1. Durinck, S. et al. Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes. Nat. Genet. 10.1038/ng.3146

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  1. Louise Stone
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Stone, L. New genomic variation found. Nat Rev Urol 12, 67 (2015). https://doi.org/10.1038/nrurol.2014.330

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