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Prostate cancer

Tools to predict insignificant prostate cancer are inaccurate in unscreened men

Nature Reviews Urology volume 11, page 246 (2014)Cite this article

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New research from the UK warns against using stratification tools developed in screened populations in men who have not undergone PSA screening. “None of the published tools we used had discriminative power in predicting insignificant prostate cancer in our cohort,” explains Benjamin Thomas, co-author of the study recently published in the British Journal of Cancer.

Thomas and colleagues were concerned that the tools currently used to identify men with insignificant prostate cancer—and, therefore, most likely to be selected to undergo active surveillance—were developed in cohorts of men who underwent PSA screening and might not be appropriate for use in patients who live in regions where such screening is not routine, such as the UK, where it has been estimated that only 6% of men undergo PSA testing.

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References

  1. Shaw, G. L. et al. Identification of pathologically insignificant prostate cancer is not accurate in unscreened men. Br. J. Cancer 10.1038/bjc.2014.192

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Authors
  1. Sarah Payton
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Payton, S. Tools to predict insignificant prostate cancer are inaccurate in unscreened men. Nat Rev Urol 11, 246 (2014). https://doi.org/10.1038/nrurol.2014.97

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