Alterations in metabolism are fundamental to the development and progression of renal cell carcinoma (RCC). Through use of a combined proteomic and metabolomic analysis approach, a new paper enhances our understanding of the metabolomic alterations that occur in RCC and highlights new therapeutic targets.
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PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma
Cell Death & Disease Open Access 11 March 2023
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Minton, D., Nanus, D. Novel targets in altered tumour metabolism in kidney cancer. Nat Rev Urol 12, 428–429 (2015). https://doi.org/10.1038/nrurol.2015.168
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DOI: https://doi.org/10.1038/nrurol.2015.168
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PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma
Cell Death & Disease (2023)