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Infection

PrEParation to be PROUD of

Nature Reviews Urology volume 12, page 596 (2015)Cite this article

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The results of the pilot stage of the PROUD study-the first pragmatic open-label randomized controlled trial investigating pre-exposure prophylaxis (PrEP) with tenofovir–emtricitabine for reducing the risk of HIV infection-have been published in The Lancet. PROUD aims to mimic how PrEP would be used in routine clinical practice to allay concerns that its effectiveness would be compromised in a real-world setting.

The pilot study included 544 HIV-negative gay men and other men who have sex with men. Participants were randomly assigned 1:1 to receive immediate PrEP or deferred PrEP. The investigators employed procedures that would be likely in a public health PrEP programme. Participants were asked to attend clinic every 3 months for an HIV test, screening for bacterial STIs and testing hepatitis B and C, if indicated. Information on sexual behaviour and adherence to PrEP was gathered via yearly and monthly questionnaires and a daily diary. The primary outcome was time to accrual and retention of participants. Secondary outcomes included HIV infection, safety, adherence and risk compensation.

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References

  1. McCormack, S. et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet 10.1016/S0140-6736(15)00056-2

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  1. Louise Stone
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Stone, L. PrEParation to be PROUD of. Nat Rev Urol 12, 596 (2015). https://doi.org/10.1038/nrurol.2015.225

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