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Prostate cancer

Wnt signalling induces resistance

Nature Reviews Urology volume 12, page 597 (2015)Cite this article

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The development of resistance to androgen-receptor (AR) targeting therapies is a major challenge to the effective treatment of patients with metastatic prostate cancer. Now, research published in Science shows that activation of noncanonical Wnt signalling in single circulating tumour cells (CTCs) from patients with prostate cancer correlates with reduced effectiveness of antiandrogen treatment.

On the reasons for studying CTCs, first author David Miyamoto explains: “Drug resistance mechanisms in metastatic prostate cancer are difficult to study owing to the predominance of bone metastases, which are challenging to biopsy;” thus, “CTCs in the blood represent a readily accessible source of tumour cells.”

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References

  1. Miyamoto, D. T. et al. RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance. Science 349, 1351–1356 (2015)

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  1. Peter Sidaway
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Sidaway, P. Wnt signalling induces resistance. Nat Rev Urol 12, 597 (2015). https://doi.org/10.1038/nrurol.2015.244

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