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Prostate cancer

SLCO2B1 variants correlate with castration resistance

Nature Reviews Urology volume 13, page 65 (2016)Cite this article

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Substantial variations exist in the overall survival (OS) of patients with metastatic prostate cancer, and the development of resistance to androgen-deprivation therapy (ADT) often portends worse OS. Now, data from a genetic association study reveal that specific genetic variants of SLCO2B1, which encodes a dehydroepiandrosterone sulphate (DHEA-S) uptake transporter, are associated with significantly shorter OS in patients with metastatic prostate cancer.

The influence of three single-nucleotide polymorphisms (SNPs) — the exonic SNP rs12422149, and the intronic SNPs rs1789693 and rs1077858 — was examined in prostatectomy samples from a study cohort of 616 patients with metastatic prostate cancer who received ADT between 1996 and 2013. Patients whose prostatectomy samples were homozygous for the G form of rs1077858 were found to have significantly worse OS from the initiation of ADT, compared with those who were either heterozygous (GA) or homozygous for the A variant of this SNP (HR 1.35; 95% CI 1.07–1.71 for GG versus AA/GA forms of rs1077858).

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References

  1. Wang, X. et al. Association of SLCO2B1 genotypes with time to progression and overall survival in patients receiving androgen-deprivation therapy for prostate cancer. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2015.62.5988

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  1. Peter Sidaway
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Sidaway, P. SLCO2B1 variants correlate with castration resistance. Nat Rev Urol 13, 65 (2016). https://doi.org/10.1038/nrurol.2015.306

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