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Testicular cancer

Origin and evolution of TGCTs

Nature Reviews Urology volume 14, page 5 (2017)Cite this article

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To identify genomic features of TGCTs that are associated with disease origin and progression, Amaro Taylor-Weiner and colleagues undertook clinically integrated molecular analysis of 59 germline-matched tumour samples from 47 men with TGCTs and two patients with primary mediastinal germ cell tumours (PMGCTs).

Mutational significance analysis revealed that the most significantly mutated gene was KRAS, and only one other gene — RPL5 — was observed to be significantly mutated. Phylogenetic analysis of whole-exome sequencing data from patient-matched germ cell neoplasia in situ showed that both tumour types had chromosome arm 12p gain but the only putative driver mutation that distinguished the two tumours was a KRAS mutation in TGCT. These results suggest that these two processes could be separate events in TGCT evolution, with mutation of KRAS occurring after chromosome 12p arm-level gain.

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References

  1. Taylor-Weiner, A. et al. Genomic evolution and chemoresistance in germ cell tumours. Nature http://dx.doi.org/10.1038/nature20596 (2016)

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  1. Louise Stone
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Stone, L. Origin and evolution of TGCTs. Nat Rev Urol 14, 5 (2017). https://doi.org/10.1038/nrurol.2016.255

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