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Prostate cancer

Glycolysis and AR expression as biomarkers

Nature Reviews Urology volume 15, page 2 (2018)Cite this article

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Assessing androgen receptor (AR) expression and glycolytic activity using PET–CT imaging could be useful for predicting the prognosis of patients with metastatic castration-resistant prostate cancer (CRPC), say researchers.

Josef Fox and co-workers enrolled 133 patients with progressive metastatic CRPC to undergo dual PET–CT imaging using 18F-fluorodeoxyglucose (18F-FDG) as an indicator of tumour glycolysis and 18F-fluorodihydrotestosterone (18F-FDHT) as an indicator of AR expression.

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References

  1. Fox, J. J. et al. Positron emission tomography/computed tomography–based assessments of androgen receptor expression and glycolytic activity as a prognostic biomarker for metastatic castration-resistant prostate cancer. JAMA Oncol. http://dx.doi.org/10.1001/jamaoncol.2017.3588 (2017)

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  1. Rebecca Kelsey
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Kelsey, R. Glycolysis and AR expression as biomarkers. Nat Rev Urol 15, 2 (2018). https://doi.org/10.1038/nrurol.2017.205

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