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Prostate cancer

Castration resistance driven by a GI transcriptional circuit

Nature Reviews Urology volume 15, page 68 (2018)Cite this article

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Aberrant expression of a gastrointestinal (GI)-lineage transcriptome, independent of androgen receptor (AR) signalling, can drive castration resistance in prostate cancer.

HNF4G binds to and maintains a cistrome that regulates a GI-lineage transcriptome

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References

  1. Shukla, S. et al. Aberrant activation of a gastrointestinal transcriptional circuit in prostate cancer mediates castration resistance. Cancer Cell http://dx.doi.org/10.1016/j.ccell.2017.10.008 (2017)

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  1. Louise Stone
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Stone, L. Castration resistance driven by a GI transcriptional circuit. Nat Rev Urol 15, 68 (2018). https://doi.org/10.1038/nrurol.2017.211

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