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Bladder cancer

Mutations in DNA-damage-repair pathways confer platinum sensitivity

Nature Reviews Urology volume 14, page 197 (2017)Cite this article

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Researchers performed next-generation sequencing (NGS) using the MSK–IMPACT platform to investigate the prevalence of somatic DDR alterations in pretreatment tumour tissue samples. Lead author Jonathan Rosenberg explains the rationale for this approach: “We have previously shown that patients with bladder cancer receiving neoadjuvant cisplatin-based chemotherapy who have mutations in DNA repair genes have outstanding pathological responses, such as major downstaging, disappearance of invasive cancer, or eradication.” Furthermore: “We sought to determine whether these findings are applicable to patients with metastatic disease treated with platinum-based chemotherapy.”

....the presence of DDR mutations is associated with better outcomes with platinum-based chemotherapy

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References

  1. Teo, M. Y. et al. DNA damage response and repair gene alterations are associated with improved survival in patients with platinum-treated advanced urothelial carcinoma. Clin. Cancer Res. http://dx.doi.org/10.1158/1078-0432.CCR-16-2520 (2017)

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  1. Peter Sidaway
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Sidaway, P. Mutations in DNA-damage-repair pathways confer platinum sensitivity. Nat Rev Urol 14, 197 (2017). https://doi.org/10.1038/nrurol.2017.22

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