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Bladder cancer

Genetic urinary biomarker panel is promising

Nature Reviews Urology volume 14, page 198 (2017)Cite this article

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A diagnostic urinary biomarker combination has been described for patients with non-muscle-invasive bladder cancer (NMIBC). The results of this study provide more evidence for the value of urine analysis as an alternative diagnostic tool to cystoscopy for patients with this disease.

In this multicentre study, 2,496 urine samples were collected from 977 patients with NMIBC before they received cystoscopy during regular visits to the clinic. These samples were analysed for FGFR3 and TERT mutations and methylation of OTX1. The sensitivity of this biomarker assay was then assessed for different subsets of patients.

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References

  1. Beukers, W. et al. FGFR3, TERT and OTX1 as urinary biomarker combination for surveillance of bladder cancer patients in a large prospective multicenter study. J. Urol. http://dx.doi.org/10.1016/j.juro.2016.12.096 (2016)

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Authors
  1. Louise Stone
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Stone, L. Genetic urinary biomarker panel is promising. Nat Rev Urol 14, 198 (2017). https://doi.org/10.1038/nrurol.2017.6

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  • DOI: https://doi.org/10.1038/nrurol.2017.6

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