Figure 1
From: Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy
An overview of CNV-affected genes in association with signaling pathways, pathological features and therapeutic targets in GC. The genes on CNV regions have been highlighted either in red (indicating gain or amplification) or green (loss or deletion). Their relationships with different signaling pathway have been shown with arrows. In addition, the relevance to disease features ('R'), targeted therapy ('T') and oncogenic functions ('F') have also been labeled for each gene. The signaling pathways related to the receptor tyrosine kinase genes (MET, EGFR, FGFR2 and HER2) have been labeled in the graph.
