DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer

Lin, Shan-Yang; Cheng, Wen-Ting; Wei, Yen-Shan; Lin, Hong-Liang

doi:10.1038/pj.2011.15

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Published: 09 March 2011

Polymer Synthesis and Reactions

DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer

Shan-Yang Lin¹,
Wen-Ting Cheng¹,
Yen-Shan Wei¹ &
…
Hong-Liang Lin¹

Polymer Journal volume 43, pages 577–580 (2011)Cite this article

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Acrylic resins containing acrylic acid (AA), methyl methacrylate (MMA) or acrylic–methacrylic copolymer are the most commonly used polymeric materials for biomedical and pharmaceutical applications owing to their hydrophilicity and biocompatibility.^{1, 2, 3, 4} Recently, a new polyvinyl alcohol (PVA) copolymer designed by copolymerizing AA and MMA with PVA was successfully developed as a capsule shell for filling liquid formulations to enhance the bioavailability of water-insoluble drugs.^{5, 6, 7} PVA was used as a skeleton in the structure of PVA copolymer; MMA and AA were separately copolymerized to increase the hardness of the capsule shell and the solubility in water. Furthermore, the PVA copolymer has also been reported to act as a binder or film-coating agent in pharmaceutical applications.^{8, 9, 10} In particular, the oxygen-blocking and light-protective properties of PVA copolymer film have increased its usage in the pharmaceutical industry.^{9, 10} The stability of PVA copolymer is another important factor for pharmaceutical applications. Because the stability of PVA copolymer may significantly influence the physico-chemical properties and efficacy of a drug after application of PVA copolymer, accelerated stability tests for PVA copolymer should be performed to predict the storage stability and quality of drug products. Accelerated stress conditions, including heat, humidity and light, have become a popular parameter for evaluating the reliability of drug products within short testing periods.^{11, 12}

Our previous study provided the first evidence of thermally induced anhydride formation in Eudragit E, a copolymer composed of butyl methacrylate, 2-dimethylaminoethyl methacrylate and MMA in the composition 1:2:1.¹³ PVA copolymer has also been copolymerized by AA and MAA with PVA,^{5, 6, 7} but the thermal stability has not yet been investigated. In the present study, a highly specialized and powerful Fourier transform infrared (FTIR) microspectroscopy equipped with a differential scanning calorimeter (DSC) was used to examine the thermal stability of PVA copolymer. Eudragit E was used for comparison.

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Department of Biotechnology, Yuanpei University, Hsin-Chu, Taiwan, PR China
Shan-Yang Lin, Wen-Ting Cheng, Yen-Shan Wei & Hong-Liang Lin

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Shan-Yang Lin
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Lin, SY., Cheng, WT., Wei, YS. et al. DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer. Polym J 43, 577–580 (2011). https://doi.org/10.1038/pj.2011.15

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Received: 10 December 2010
Revised: 13 January 2011
Accepted: 14 January 2011
Published: 09 March 2011
Issue date: June 2011
DOI: https://doi.org/10.1038/pj.2011.15

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DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer

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This article is cited by

The effect of end group and graphene on dielectric properties and thermal degradation of poly(benzyl methacrylate) prepared by ATRP method

Influence of pentaerythritol on the properties of polyvinyl alcohol films for the polarizers

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