Cytochrome oxidase redox state (Cu_A) correlates with the severity of delayed cerebral energy failure following transient hypoxia-ischaemia (HI) in the newborn piglet. 230

Background: Transient HI leads to a delayed decline in cerebral nucleotide triphosphate (NTP)/exchangeable phosphate pool (EPP) ratios measured by phosphorus magnetic resonance spectroscopy (MRS). We measured changes in Cu_A during the development of delayed energy failure in order to investigate the relationship between mitochondrial cytochrome redox state and cerebral phosphorus high energy metabolites.

Subjects and Interventions: 6 piglets aged <24h were anaesthetized and subjected to a transient episode of cerebral HI followed by resuscitation and maintenance of intensive support. NTP/EPP ratio was measured by MRS and Cu_A changes from baseline determined with a multichannel near infrared spectrometer (600-1000nm). Table

Table 1

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