CARDIOPULMONARY RESPONSE TO EXERCISE AFTER THE MODIFIED FONTAN OPERATION: A MULTIVARIATE ANALYSIS OF THE DETERMINANTS OF PERFORMANCE IN 60 PATIENTS. † 149

We describe the pre- and postoperative determinants of cardiorespiratory function after the modified Fontan operation for 60 patients operated at Mayo Clinic between 1985 and 1993. The patients were 5 to 41 years of age(m=[horizontal bar over]14 yr.) at the time of exercise. Exercise was performed 0.8 to 15 years following operation (m=[horizontal bar over]6.4±2.9yr.). The dependent variables at peak exercise included: O₂ consumption (˙VO₂/kg^2/3), systemic arterial O₂ sat and HR. We analyzed 126 pre- and 61 postoperative independent variables. Multiple linear regression using a stepwise approach was used to identify predictive variables.

Results: At peak exercise ˙VO₂/kg^2/3 was 0.086±0.022(0.040 to 0.139) l/min/kg^2/3, O₂ sat was 89.5±4.1(77-96)% and HR was 147.8±24.4(79-188) bpm. At a p value< 0.05, there were no significant predictors for HRmax. The predictors for˙VO₂/kg^2/3 and O₂ sat are shown in thetable:

Table 1

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