Noninvasive Motion Ventilation (NIMV), a Novel Method of Ventilation: Use in a Piglet Meconium Aspiration Syndrome (MAS) 1592

Non invasive motion ventilation (NIMV) (Nims, Miami Beach FL) is a new method of ventilatory support that does not require cycling positive pressure being directly applied to the airway. Ventilation is achieved through movements of the diaphragm from shifts of abdominal contents created by horizontal headwards-footwards motion of a platform at 4- 10Hz. This technique has been a success in paralyzed, normal piglets. This study assesses feasibility in the MAS model. 5 anesthetized piglets, 1.8-2.1 kg, had vascular catheters placed, and tracheotomy done for the purpose of measuring volumes and providing CPAP 5 cm H₂O. The animals were paralyzed and placed on conventional mechanical ventilation with FiO₂ 100%. Baseline (BL) arterial blood gases (ABG) and respiratory mechanics were done, followed by intratracheal administration of 2ml/kg of a 20% solution of human mecomium; these were repeated after 15-20 min (MEC). The piglets were then begun on NIMV at 5-7 Hz, CPAP 5 cm H₂O and FiO₂ 100% bias flow, without changes in these settings during the subsequent 150-min. Total respiratory compliance decreased from 2.4(1.0) at BL to 1.0(0.2) ml/cmH₂O/kg post MEC (p<0.001). Data: [Mean (SD)] (*p<0.05 BL vs. MEC and **MEC vs. Time). BPm =mean blood pressure (mmHg) Therefore, NIMV is a promising method of ventilatory support even in lungs with significantly decreased compliance, and, has the potential for avoidance of barotrauma that may be associated with conventional mechanical ventilators, which cycle high positive pressures. Table

Table 1 No caption available.

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