To The Editor: We would like to thank Dr. Vavilala and colleague for their interest in our manuscript. Their letter raises a number of points primarily concerning the methodology of our study (1).

The first question they raise is how CO2 reactivity was examined. The multiple-regression model used paired values of blood pressure and PaCO2 measured contemporaneously with CBF measurements (1). In this way, we hoped to determine the individual effects of these predictor variables on our outcome variable (CBF).

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