Abstract
Background and aims: Trans isomers may disturb the metabolism of n-3 and n-6 polyunsaturated fatty acids (PUFAs), so our aim was to investigate whether maternal trans fatty acid status is associated to the cord blood PUFA supply.
Methods: Expecting mothers were supplemented with either fish oil (FO, n = 36) or with 5-methyltetrahydro folic acid (5-MTHF, n = 25) or both (FO+5- MTHF, n = 34) or placebo (n = 30) from the 20th week of gestation onwards. The fatty acid composition of erythrocyte membrane phosphatidylethanolamine lipids of maternal blood at delivery and cord blood was determined with gas chromatography.
Results: There were no significant correlations between maternal C18:1n-7/9t and cord blood C18:2n-6 and C20:4n-6 values in the four supplementation groups. In contrast, we found significant inverse correlations between maternal C18:1n-7/9t and C22:5n-3 values in the cord blood in all supplementation groups (table). The values of maternal C18:1n-7/9t correlated significantly and inversely to cord blood C22:6n-3 in the FO and FO+5-MTHF groups (table).
a=p< 0.05, b=p< 0.01, c=p< 0.001
Conclusion: Because maternal trans fatty acids correlated inversely to cord blood n-3, but not to n-6 PUFAs, we speculate that maternal trans isomers may adversely effect n-3 PUFA supply to the fetus.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marosvölgyi, T., Szabó, É., Campoy, C. et al. 392 Associations Between Maternal Trans Isomers and Cord Blood Polyunsaturated Fatty Acids at Birth. Pediatr Res 68 (Suppl 1), 202 (2010). https://doi.org/10.1203/00006450-201011001-00392
Issue date:
DOI: https://doi.org/10.1203/00006450-201011001-00392
