415 Abnormal Lipid Composition of Hdl Subclasses in Children with Metabolic Syndrome is Independent of Srbi (+1050T/C) and Adiponectin (+45T/G, +246G/T)Polymorphisms.

Abstract

Background: SRBI and adiponectin regulate HDL metabolism but little is known about their role on the abnormal HDL size distribution in children with metabolic syndrome (MS).

Aims: to determine lipids of HDL subclasses and establish whether SRBI (+1050T/C) and adiponectin (+45T/G, +246G/T) polymorphisms contribute to HDL lipidic composition.

Methods: Fifty MS children (IDF criteria), mean age=11.3±3.2y and 50 controls matched by age and gender were included. New enzymatic methods were developed to stain the lipids of HDL subclasses on gel surface.

Results:

Table

Table

The HDL subclasses cholesterol-to-phospholipid ratio was lower in patients, (p< 0.001). +1050T carriers of the SR-BI gene polymorphism were more frequent in MS group (64% vs 33%, p=0.004).

However, SR-BI polymorphisms did not correlate with HDL lipids. Adiponectin gene polymorphisms were similar between MS and control subjects.

Conclusion: MS in children is associated with low plasma concentration of HDL subclasses cholesterol, independently of SRBI and adiponectin polymorphisms. Our data strongly suggest an abnormal HDL structure in MS that may be related with and impaired function of these lipoproteins.

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