Abstract
Background: The unreleased algorithm (WINROP) uses gestation age (GA), birth weight (BW) and early weight gain (EWG; absolute weekly weight gain in the first 6 weeks) to predict development of ROP requiring treatment (ROP-T). In predominantly white infants, it is reported to predict ROP-T with 100% sensitivity and 80% specificity (1,2).
Aim: To explore the relationship between maternal ethnicity (ME), GA, BW and EWG and ROP-T in a multiracial population.
Methods: A retrospective record review of babies screened for ROP at two tertiary neonatal units serving multiracial populations in North East London. Analysis was performed using unpaired t-test and logistic regression
Results: Mean (±SD) GA, BW, and EWG were significantly lower in ROP-T babies compared with those who did not require ROP treatment (ROP-C) (Table).
On logistic regression, GA (p< 0.001), BW (p< 0.001) and ME (p=0.01) were significant predictors for development of ROP-T, whereas EWG was not. An increase of 1 week GA, 100 grams of birthweight and being born to black mother resulted in reduction of odds of development of ROP-T from 1 to 0.49, 0.53 and 0.15 respectively.
Conclusions: In our multiracial population, GA, BW and non-black ME were significant predictors for the development of ROP-T but early weight gain was not.
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References
Hellstrom, et al. Pediatrics 2009
Wu et al. Arch Ophthalmol 2010
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Sinha, A., Arora, P., Lopez, W. et al. Relationship between Maternal Ethnicity, Gestation Age, Birth Weight and Early Weight Gain and Development of Retinopathy of Prematurity Requiring Treatment in a Multiracial Population. Pediatr Res 70 (Suppl 5), 729 (2011). https://doi.org/10.1038/pr.2011.954
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DOI: https://doi.org/10.1038/pr.2011.954
