Abstract
Background
Little is known on amplitude-integrated electroencephalography (aEEG) during the first few days after birth in neonates with congenital heart disease (CHD). Our aim was, therefore, to assess electrocortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG.
Methods
Neonates with CHD who were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included. We assessed aEEG background patterns, sleep–wake cycling, and epileptic activity during the first 72 h after birth and defined prenatal and postnatal clinical parameters associated with aEEG patterns.
Results
Seventy-two neonates were included. Twenty-six (36%) had mildly abnormal and six (8%) had severely abnormal aEEG background patterns at some point during the study period. Sleep–wake cycling was present in 97% of the neonates. Subclinical seizures were common (15%), whereas none of the neonates had clinical seizures. Only treatment with sedatives was a significant predictor for abnormal aEEG background patterns, explaining 56% of the variance.
Conclusion
Abnormal aEEG background patterns are common and are strongly associated with treatment with sedatives in neonates with prenatally diagnosed CHD. Future studies should assess the association between early postnatal aEEG abnormalities and neurodevelopmental outcome.
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Acknowledgements
This study was part of the research program of the Graduate School of Medical Sciences, Research Institutes BCN-BRAIN and GUIDE, and University of Groningen.
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M.J.M. and S.J.K. were financially supported by the Junior Scientific Master Class of the University of Groningen.
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Mebius, M., Oostdijk, N., Kuik, S. et al. Amplitude-integrated electroencephalography during the first 72 h after birth in neonates diagnosed prenatally with congenital heart disease. Pediatr Res 83, 798–803 (2018). https://doi.org/10.1038/pr.2017.311
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DOI: https://doi.org/10.1038/pr.2017.311
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