Fig. 4: Simulation of Myh1+/+ and Myh1−/− outer hair cells in response to sound stimulus.
From: MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss
a Illustration of the outer hair cell (OHC) circuit. gMET conductance of the mechanoelectrical transducer (MET) channel, gK,s conductance of the small conductance K+ channel, gK,n conductance of IK,n, corresponding to the KCNQ4 channel, Cm cell membrane capacitance, EP endocochlear potential, EK K+ reversal potential, Vm basolateral membrane potential. b Stimulation of stereocilia at 1000 Hz for 200 ms. c Membrane potential oscillation by 1000 Hz stereocilia stimulation. d MET channel gating induced by 1000 Hz stereocilia stimulation. e K+ channel gating induced by 1000 Hz stereocilia stimulation. f Membrane capacitance oscillation induced by 1000 Hz stereocilia stimulation. g OHC electromotility power at 1000 Hz stereocilia stimulation. h OHC electromotility power across different frequencies of stereocilia stimulation. i Normalized electromotility power of Myh1−/− OHCs compared to Myh1+/+ OHCs across different frequencies. In (b–h), Myh1+/+ OHCs are indicated by black lines, and Myh1−/− OHCs are indicated by red lines.
