Fig. 5: Molecular dynamics simulation of identified MYH1 variants.
From: MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss
a Location of the MYH1 variants in terms of the domain structure and amino acid conservation across other vertebrates. b The overall architecture of MYH1 (residues 1–843) predicted using AlphaFold2. The variant residues are indicated. c Root mean square deviation (RMSD) analysis of a 100 ns MD simulation of the wild-type and mutant MYH1 proteins. d Root mean square fluctuation (RMSF) analysis of the last 50 ns. e Principal component analysis (PCA) of MD simulation trajectories.
