Fig. 3: Downregulation of genes involved in the NF-κB pathway across all cell types. | Experimental & Molecular Medicine

Fig. 3: Downregulation of genes involved in the NF-κB pathway across all cell types.

From: Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics

Fig. 3

a Heatmap displaying the expression levels of DEGs that were significantly different between S0 and S1 CD4+ T cells and categorized by treatment duration and biologic conditions. The top 20 downregulated and upregulated DEGs in CD4+ T S1 cells compared with S0 cells are shown on the y-axis. b Top 5 MSigDB hallmark 2020 pathways and their p values associated with upregulated DEGs in State 0. The y-axis represents the names of the pathways, and the x-axis represents the −log10 of their p values. Each pathway has two bars representing p values calculated for upregulated DEGs in S0 (red) and S1 (turquoise). c The top 5 TRRUST transcription factors and their p values associated with upregulated DEGs in S0 (red). The turquoise bars represent p values of the corresponding pathways associated with upregulated DEGs in State 1.

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