Fig. 4: Different effects of biologics on CD4+ T cells according to their mechanisms of action. | Experimental & Molecular Medicine

Fig. 4: Different effects of biologics on CD4+ T cells according to their mechanisms of action.

From: Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics

Fig. 4

a Dimension plots of CD4+ T S1 cells plotted according to subtype (left panel) and biologics type (right panel). On the right panel, the cells associated with mepolizumab/reslizumab and dupilumab are colored red and turquoise, respectively. b Pie charts show the frequencies of the subtypes according to the biologics type. c Dot plots of DEGs included in the MSigDB hallmark 2020 pathways were significantly associated with upregulated DEGs in TCM S1 cells compared with naïve S1 cells (the first five), and vice versa (the last). The colored bars and circles represent the average expression and percent expression of the corresponding genes according to subtype, respectively. d Chord plots of the MHC-II signaling pathway network of the 0/1 M and 6 M groups of the mepolizumab/reslizumab and dupilumab groups. e Chord plots of the CD40 signaling pathway network of the 0/1 M and 6 M groups in patients in the mepolizumab/reslizumab and dupilumab groups. S0 and S1 represent States 0 and 1, respectively.

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