Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Bariatric Surgery

Response to the Letter by Yi Wang: “Reflections on ‘sex-differential testosterone response to long-term weight loss’: illuminating findings and considered limitations”

International Journal of Obesity volume 49, pages 538–539 (2025)Cite this article

Subjects

Access through your institution
Buy or subscribe

We appreciate Yi Wang’s insightful reflections on our recent manuscript, “Sex-differential testosterone response to long-term weight loss,” and his thoughtful consideration of its findings. While we recognize the valuable suggestions, we would like to provide further clarification on the scope and intent of our study, particularly in light of the existing gaps in the literature.

Our study aimed to address the relative scarcity of data examining long-term changes in sex hormones, with a follow-up period exceeding 12 months. This is an area with limited prior research, particularly regarding hormonal responses to weight loss interventions. Our cohort included participants who underwent three of the most commonly performed bariatric procedures, as well as those who engaged in dietary interventions. The weight loss outcomes observed in our cohort were comparable to those reported in randomised controlled studies of patients undergoing these interventions [1].

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Schauer PR, Bhatt DL, Kirwan JP, Wolski K, Brethauer SA, Navaneethan SD, et al. Bariatric surgery versus intensive medical therapy for diabetes-3-year outcomes. N. Engl J Med. 2014;370:2002–13.

    PubMed  PubMed Central  Google Scholar 

  2. Malik SM, Traub ML. Defining the role of bariatric surgery in polycystic ovarian syndrome patients. World J Diabetes. 2012;3:71–9.

    PubMed  PubMed Central  Google Scholar 

  3. McCartney CR, Marshall JC. Clinical practice. Polycystic ovary syndrome. N. Engl J Med. 2016;375:54–64.

    PubMed  PubMed Central  Google Scholar 

  4. Di Vincenzo A, Busetto L, Vettor R, Rossato M. Obesity, male reproductive function and bariatric surgery. Front Endocrinol. 2018;9:769.

    Google Scholar 

  5. Kochkodan J, Telem DA, Ghaferi AA. Physiologic and psychological gender differences in bariatric surgery. Surg Endosc. 2018;32:1382–8.

    PubMed  Google Scholar 

  6. Still CD, Wood GC, Benotti P, Petrick AT, Gabrielsen J, Strodel WE, et al. Preoperative prediction of type 2 diabetes remission after Roux-en-Y gastric bypass surgery: a retrospective cohort study. Lancet Diabetes Endocrinol. 2014;2:38–45.

    PubMed  PubMed Central  Google Scholar 

  7. Brysbaert M, Stevens M. Power analysis and effect size in mixed effects models: a tutorial. J Cogn. 2018;1:9.

    PubMed  PubMed Central  Google Scholar 

Download references

Funding

National Health and Medical Research Council (NHMRC) Scholarship for Dr MM Brzozowska.

Author information

Authors and Affiliations

  1. Garvan institute of Medical Research, Darlinghurst, NSW, Australia

    Malgorzata M. Brzozowska, Dana Bliuc, Paul A. Baldock, John A. Eisman, Jerry R. Greenfield & Jacqueline R. Center

  2. Sutherland and St George Hospitals, Sydney, NSW, Australia

    Malgorzata M. Brzozowska

  3. Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia

    Malgorzata M. Brzozowska, Dana Bliuc, Paul A. Baldock, John A. Eisman, Jerry R. Greenfield & Jacqueline R. Center

  4. Faculty of Medicine, University of Rzeszow, Rzeszow, Poland

    Artur Mazur

  5. School of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia

    Paul A. Baldock, John A. Eisman & Jacqueline R. Center

  6. Department of Endocrinology, St Vincent’s Hospital Clinical School, Darlinghurst, NSW, Australia

    John A. Eisman, Jerry R. Greenfield & Jacqueline R. Center

Authors
  1. Malgorzata M. Brzozowska
    View author publications

    Search author on:PubMed Google Scholar

  2. Dana Bliuc
    View author publications

    Search author on:PubMed Google Scholar

  3. Artur Mazur
    View author publications

    Search author on:PubMed Google Scholar

  4. Paul A. Baldock
    View author publications

    Search author on:PubMed Google Scholar

  5. John A. Eisman
    View author publications

    Search author on:PubMed Google Scholar

  6. Jerry R. Greenfield
    View author publications

    Search author on:PubMed Google Scholar

  7. Jacqueline R. Center
    View author publications

    Search author on:PubMed Google Scholar

Contributions

Study design: MMB, JRC, JC, PAB, JAE, DB. Study conduct: MMB. Data collection: MMB. Data analysis: MMB, DB, Data interpretation: MMB, JRC, JRG, PAB, DB, JAE, AM. Drafting manuscript: MMB. Revising manuscript content: MMB, JRC, JRG, PAB, DB, JAE, AM. Approving final version of manuscript: all authors. MMB is the guarantor of this work.

Corresponding author

Correspondence to Malgorzata M. Brzozowska.

Ethics declarations

Competing interests

Dr. MM Brzozowska, Dr D Bliuc, A/Prof. PA Baldock, Prof A Mazur, Prof J Greenfield have no competing of interests to report. Prof JA Eisman and Prof JR Center disclosed relevant financial interests outside this body of work. Prof. JR Center has received honoraria for educational talks and/or been on Advisory boards from Amgen and Theramex/Teva. Prof. JA Eisman received consulting and research support from Amgen, Eli Lilly, Merck Sharp and Dohme and Novartis. This does not alter our adherence to the IJO on sharing data and materials.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Brzozowska, M.M., Bliuc, D., Mazur, A. et al. Response to the Letter by Yi Wang: “Reflections on ‘sex-differential testosterone response to long-term weight loss’: illuminating findings and considered limitations”. Int J Obes 49, 538–539 (2025). https://doi.org/10.1038/s41366-024-01692-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41366-024-01692-3

Search

Advanced search

Quick links