Fig. 1: Male Surmount 1 representative participant at baseline and at 72-weeks of the treatment protocol [2].

The participant age, weight, height, and waist circumference (WC) as outlined in Table 1 were used to generate the 3D images with manifold regression. BMI is body mass index. Waist circumference at the 72-week evaluation was predicted using a multiple regression model shown in Supplementary Information II. Data were reported earlier by Chao et al. [16] and Garcia-Perez [15].