Table 1 Effects of sleeve gastrectomy vs. Roux-en-y gastric bypass on different aspects.

From: Mechanisms of metabolic surgery effectiveness in obesity and type 2 diabetes: a puzzle with some known pieces

• After SG, unlike RYGB, the NTS sprouts new vagal afferents (an increase in axon collaterals) and forms new synapses [23].

• After SG, the level of circulating ghrelin is reduced to a greater extent than that after RYGB [106].

• Unlike RYGB, fasting in SG was not associated with an increase in ghrelin concentration [107].

• After RYGB, unlike SG, functional MRI shows reduced activation of the ventral tegmental dopaminergic area and of the dorsal striatum induced by caloric food [43].

• The effect of changing eating behavior is more pronounced after RYGB than after SG [60].

• Other effects on enterohormone levels:

SG: lower concentrations of GLP-1 [104].

SG: marked elevation of GIP (unaffected after RYGB) [105].

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