Table 5 Adjusted risk ratios of allergic conditions associated with a twofold increase in postnatal phthalates and bisphenols.

From: Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies

 

Asthma

Wheeze

 

Cohorts

N

RR (95%CI)

Cohorts

N

RR (95%CI)

DEP

2

1175

0.98 (0.93–1.03)

2

1719

0.99 (0.95–1.03)

DBP

2

1098

1.11 (0.99–1.25)

2

1589

1.03 (0.96–1.09)

BBzP

2

1184

0.98 (0.93–1.03)

2

1720

1.05 (1.01–1.09)

DEHP

2

1179

1.01 (0.95–1.09)

2

1718

1.06 (1.01–1.11)

MCPP

2

1184

1.06 (0.98–1.16)

2

1719

1.09 (1.04–1.14)

BPA

1

235

0.89 (0.78–1.01)

1

303

0.98 (0.90–1.06)

 

Eczema

Rhinitis

 

Cohorts

N

RR (95%CI)

Cohorts

N

RR (95%CI)

DEP

2

1707

1.00 (0.97–1.02)

2

1273

1.00 (0.96–1.04)

DBP

2

1576

1.01 (0.97–1.06)

2

1149

1.04 (0.94–1.16)

BBzP

2

1707

0.98 (0.95–1.00)

2

1280

0.99 (0.95–1.04)

DEHP

2

1705

0.95 (0.91–0.98)

2

1276

0.99 (0.94–1.05)

MCPP

2

1707

0.95 (0.92–0.98)

2

1279

0.98 (0.93–1.04)

BPA

1

303

1.00 (0.95–1.06)

1

303

1.03 (0.98–1.09)

  1. Models obtained with generalised estimating equations. Models adjusted for cohort membership, maternal age, ethnicity, parental education, marital status, family history of asthma, sex, prenatal tobacco smoke exposure, season of birth, breastfeeding duration, age at outcome assessment, postnatal smoke exposure and gestational age. All exposures are modelled as estimated daily intakes, except MCPP, which is modelled using biomarker concentrations.
  2. BBzP Benzyl butyl phthalate, BPA Bisphenol A, DBP Dibutyl phthalate, DEHP Di(2-ethylhexyl) phthalate, DEP Diethyl phthalate, DMP Dimethyl phthalate, MCPP Mono(3-carboxypropyl) phthalate, RR Risk Ratios.
Back to article page