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Methodological flaws in a meta-analysis compromise the integrity of the evidence

Journal of Perinatology (2025)Cite this article

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TO THE EDITOR:

We read with interest the recent meta-analysis by Sivakumar et al. [1] exploring the interventions for neonatal hypoglycemia. The author’s efforts to synthesize the evidence on this important topic are commendable. We would like to share a few methodological considerations that we believe may further enrich interpretation and contribute to the evidence in this field.

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References

  1. Sivakumar G, Kuppusamy P, P LP, Mishra A, Sivakumar S. Effectiveness of oral dextrose gel for neonates at risk of hypoglycemia: a systematic review, meta-analysis, and GRADE assessment of randomized controlled trials. J Perinatol. 2025;45:1335–44.

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Authors and Affiliations

  1. Neonatal Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Kirti Pai, Alok Raghav & Jogender Kumar

Authors
  1. Kirti Pai
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  2. Alok Raghav
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  3. Jogender Kumar
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Contributions

KP: conceptualized the correspondence, drafted and critically revised the manuscript; AR: provided methodological input and contributed to the literature review and synthesis; JK: conceptualized the correspondence, reviewed for accuracy, supervised revisions, and approved the final version.

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Correspondence to Kirti Pai.

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Pai, K., Raghav, A. & Kumar, J. Methodological flaws in a meta-analysis compromise the integrity of the evidence. J Perinatol (2025). https://doi.org/10.1038/s41372-025-02524-6

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