Fig. 2 | Laboratory Investigation

Fig. 2

From: Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial–mesenchymal transition

Fig. 2

HB-EGF expression and collagen deposition in the lung tissues of patients with COPD. The localization of HB-EGF in the lung tissues was investigated by immunostaining. Photomicrographs of blue staining showing collagen expression around the small airway walls. Representative photographs are shown (a). (all images are ×400 magnification). HB-EGF expression and collagen deposition in the lung tissues were quantified using the Image Pro 6.1 software (b–e). The relationship between HB-EGF expression and collagen deposition was assessed by Spearman’s test (f, g). Data were presented as the mean ± SEM

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