Fig. 4: Identification of transcriptional features related to response to therapy. | Leukemia

Fig. 4: Identification of transcriptional features related to response to therapy.

From: Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance

Fig. 4

A Heat map displaying a subset of differentially expressed genes in sc-transcriptomic profiles of tumor cells from non-responders (NR) and responders (R) to therapy. The size of the dot indicates the percentage of cells with detectable expression, and the color shows the z-scored average (log2) normalized expression within a group. B Box and Whisker plots displaying the expression fold change of selected genes in diagnostic specimens of NR versus R, as detected by qRT-PCR. A Mann-Whitney U Test was used to compare data sets pairwise (*p < 0.05).

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