Fig. 2: TTFT analysis of CLL patients in the training cohort stratified according to their light chain mutational status. | Leukemia

Fig. 2: TTFT analysis of CLL patients in the training cohort stratified according to their light chain mutational status.

From: Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement

Fig. 2

A Kaplan-Meier curve of the light chain mutational status in terms of TTFT in Binet A patients using the optimal cut-off of identity. UM light chains patients ( ≥ 99.0%) are represented by the red curve and M light chains patients ( < 99.0%) are represented by the blue curve. B Kaplan-Meier curve of TTFT according to the combined heavy and light chain mutational status. Patients with M light chain genes and M heavy chain genes are represented by the blue curve, patients with UM light chain genes and UM heavy chain genes are represented by the red curve, and discordant cases (i.e. patients with M light and UM heavy chain genes or patients with UM light and M heavy chain genes) are represented by the yellow curve. The pairwise log-rank statistics p values are indicated in the tables adjacent to the curve. C Forest plot multivariate analysis in terms of TTFT of light chain mutational status and the IPS-E variables.

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