Fig. 1: Bcor loss in TCL1 leukemic mice triggers CLL toward a high-grade lymphoid malignancy. | Leukemia

Fig. 1: Bcor loss in TCL1 leukemic mice triggers CLL toward a high-grade lymphoid malignancy.

From: Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice

Fig. 1

A FC1 analysis of CD19+ CD5+ cells in TCL1 vs Bcor−/−;TCL1 mice at different time-points in (i) PB2 at 0–-6 months (N = 17, 14), 6–12 months (N = 10, 10) and >12 months (N = 11, 9); (ii) spleen at 0-6 months (N = 17, 14), 6–12 months (N = 9, 9) and >12 months (N = 11, 12); (iii) BM3 at 0-6 months (N = 17, 14), 6–12 months (N = 9, 9) and >12 months (N = 11, 12); Mean ± SD4. P values are indicated above each graph according to Mann-Whitney U test. (B) Representative images of H&E5 staining of spleen magnification 20× (N = 2 for each genotype; left panels) and 40× (N = 3 for each genotype; right panels): sections from TCL1 (upper panels) and Bcor−/−;TCL1 (bottom panels) mice. UPlanApo 40×/0.85 NA objective, Olympus BX-51 microscope. (C) OS6 curve of Bcor−/−;TCL1 (N = 25) compared to Bcor+/+ (N = 19), Bcor−/−(N = 25) and TCL1 (N = 20) controls. Survival curves are compared using a Long-rank (Mantel-Cox) test. 1Flow cytometry; 2Peripheral Blood; 3Bone Marrow; 4Standard Deviation; 5Hematoxylin and Eosin; 6Overall survival.

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