Fig. 2: Bcor−/−; TCL1 transplanted mice closely mimic RT found in humans phenotypically. | Leukemia

Fig. 2: Bcor−/−; TCL1 transplanted mice closely mimic RT found in humans phenotypically.

From: Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice

Fig. 2

(A) Representative images of spleen (left) and scatter dot plot graph showing spleen/body weight ratios (right) of Bcor−/−; TCL1 (N = 10) compared to TCL1 (N = 8) transplanted mice. P value is indicated above the graph according to Mann-Whitney U test. (B) Representative images of H&E1 staining of spleen (left; magnification 40×) and liver (right; magnification 20×) sections from TCL1 (upper panels) and Bcor−/−;TCL1 (bottom panels) transplanted mice (N = 3, respectively). UPlanApo 40×/0.85 NA objective, Olympus B×-51 microscope. (C) OS2 curves of Bcor−/−;TCL1 (N = 18) compared to TCL1 (N = 9) transplanted mice showing a median survival of 36 (range 30–69; 5.56% of survival at day 75) vs 74 (range 67–74; 20% of survival at day 75) days, respectively. Survival curves were compared using a Long-rank (Mantel-Cox) test. 1Hematoxylin and Eosin; 2Overall survival.

Back to article page