Fig. 3: Transcriptomic profile of Bcor−/−; TCL1 mice mimic human RT. | Leukemia

Fig. 3: Transcriptomic profile of Bcor−/−; TCL1 mice mimic human RT.

From: Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice

Fig. 3

A Heatmap of selected DEGs1 (FDR2 q < 0.05) showing upregulation of Ccnd2 (log2FoldChange = 1.887; padj < 0.0001), Ccnb1 (log2FC = 1.505; padj < 0.0001), Ccnd3 (log2FC = 1.546; padj < 0.0029), Cdk1 (log2FC = 1.328; padj = 0.0001), Cdk6 (log2FC = 2.324; padj < 0.0001), and downregulation of Cdkn1a (log2FC = −1.885; padj = 0.0003), Cdkn2b (log2FC = −1.621; padj < 0.0001) in splenic B cells sorted from Bcor−/−;TCL1 compared to TCL1 mice (N = 3, both). B Bar graph showing NES3 of deregulated pathways (“Oxidative Phosphorylation” NES = 1.19; “Glycolysis” NES = 1.06; “Generation of precursor metabolites and energy” NES = 1.15; “DNA Damage Repair” NES = 1.13; “mTORC1 Signalling” NES = 1.26; “Aerobic Respiration” NES = 1.41; “G2M_Checkpoint” NES = 1.66; “E2F Targets” NES = 1.92; “MYC_Targets” NES = 2.07; “Plasma Membrane Organization” NES = −1.64; “BCR Signaling Pathway” NES = −1.63; “Antigen Activates BCR Signaling” NES = −1.73; “Adaptive_Immune_System” NES = −1.89 “Mitochondrial_Translation” NES = 1.42) resulted from pathway enrichment analysis in splenic sorted B cells from Bcor−/−;TCL1 compared to TCL1 mice (N = 3, both) after RNA-seq analysis. 1Differential Expressed Genes; 2False Discovery Rate; 3Normalized Enriched Score.

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