Table 5 Dose intensity.
A. Asciminib plus nilotinib | ||||
Median dose intensity, mg/day | ASC 20 mg BID + NIL 300 mg BID (n = 12) | ASC 40 mg BID + NIL 300 mg BID (n = 14) | ||
ASC | NIL | ASC | NIL | |
48.6 | 597.7 | 78.9 | 591.2 | |
B. Asciminib plus imatinib | ||||||||
Median dose intensity, mg/day | ASC 40 mg BID + IMA 400 mg QD (n = 6) | ASC 40 mg QD + IMA 400 mg QD (n = 9) | ASC 60 mg QD + IMA 400 mg QD (n = 6) | ASC 80 mg QD + IMA 400 mg QD (n = 4) | ||||
ASC | IMA | ASC | IMA | ASC | IMA | ASC | IMA | |
74.1 | 395.9 | 40.0 | 398.5 | 60.0 | 389.3 | 60.1 | 390.7 | |
C. Asciminib plus dasatinib | ||||||
Median dose intensity, mg/day | ASC 40 mg BID + DAS 100 mg QD (n = 11) | ASC 80 mg QD + DAS 100 mg QD (n = 15) | ASC 160 mg QD + DAS 100 mg QD (n = 6) | |||
ASC | DAS | ASC | DAS | ASC | DAS | |
79.1 | 91.6 | 79.9 | 99.4 | 157.3 | 75.4 | |
